Effects of levetiracetam on spike and wave discharges in WAG/Rij rats
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چکیده
منابع مشابه
Effects of levetiracetam on spike and wave discharges in WAG/Rij rats
Effects of the novel anti-epileptic drug levetiracetam (50 and 100 mg/kg) on spike and wave discharges (SWDs) of WAG/Rij rats were studied. Levetiracetam decreased the incidence, average duration, total duration and peak frequency of the SWDs. There was no difference between the two doses. These results agree with results obtained in Genetic Absence Epilepsy Rat from Strasbourg (GAERS). Further...
متن کاملSpike-wave discharges and sleep spindles in rats.
Sleep spindles and spike-wave discharges are thought to originate from the same thalamic pacemaker. In the present work it is investigated whether sleep spindles and spike-wave discharges are also sensitive for the same drugs. Adult male WAG/Rij rats were chronically implanted with frontal and occipital EEG electrode pairs. Rats were intraperitoneally injected with clonidine (0.00625 mg/kg), ph...
متن کاملSpike-wave discharges and sleep spindles in rats
Sleep spindles and spike-wave discharges are thought to originate from the same thalamic pacemaker. In the present work it is investigated whether sleep spindles and spike-wave discharges are also sensitive for the same drugs. Adult male WAGIRij rats were chronically implanted with frontal and occipital EEG electrode pairs. Rats were intraperitoneally injected with clonidine (0.00625 mgkg), phe...
متن کاملSleep deprivation and spike-wave discharges in epileptic rats.
The effects of sleep deprivation were studied on the occurrence of spike-wave discharges in the electroencephalogram of rats of the epileptic WAG/Rij strain, a model for absence epilepsy. This was done before, during and after a period of 12 hours of near total sleep deprivation. A substantial increase in the number of spike-wave discharges was found during the first 4 hours of the deprivation ...
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ژورنال
عنوان ژورنال: Seizure
سال: 2004
ISSN: 1059-1311
DOI: 10.1016/j.seizure.2004.02.001